Supplementary Files.

Supplementary Datasheet 1. SNPs numbers of GM and GM-associated metabolites for four outcomes.
Supplementary Datasheet 2. Causal effects of all GMs and GM-associated metabolites on four outcomes.
Supplementary Datasheet 3. Sensitivity and causal direction analysis results including all GMs.
Supplementary Datasheet 4. Sensitivity and causal direction analysis results including all GM-associated metabolites.
Supplementary Datasheet 5. SNPs used for inflammatory factor mediation analysis.
Supplementary Datasheet 6. SNPs used for immune cell mediation analysis.
Supplementary Datasheet 7. SNPs used for plasma protein mediation analysis.
Supplementary Datasheet 8. SNPs information supplementary of significant causal associations between GMs or associated metabolites and outcomes.
Supplementary Datasheet 9. Basic information of clinical patients included in this research.
Supplementary Table 1. Numbers of GM types at different taxonomic levels and corresponding Bonferroni-corrected significance thresholds.
Supplementary Figure 1. Statistical analysis of clinical patient basic information. (A-D). Statistical analysis of IVDD patient basic information.(E-H). Statistical analysis of CDD patient basic information.