Transcripts identified by microarray analysis that were deregulated in E13.5 Pax-2cre;Fgfr1(fl/?);Fgfr2(fl/fl) (Fgfr2cKO) ureters.

Evaluation of the transcriptional changes in E13.5 ureters upon loss of Fgfr2 (and reduction of Fgfr1) in the ureteric mesenchyme. Total RNA from dissected ureters of E13.5 Fgfr2cKO and control mice was analyzed by microarray analysis. Please note that the "?" (in the genotype) represents either "+" or "fl" since both Pax2cre/+;Fgfr1/+;Fgfr2fl/fl and Pax2cre/+;Fgfr1fl/fl;Fgfr2fl/fl ureters were collected together into the mutant pool.本数据集针对输尿管间充质中成纤维细胞生长因子受体2（fibroblast growth factor receptor 2, Fgfr2）缺失且成纤维细胞生长因子受体1（fibroblast growth factor receptor 1, Fgfr1）表达降低的情况，评估了其对胚胎第13.5天（E13.5）小鼠输尿管转录组变化的影响。研究人员采用微阵列分析（microarray analysis），对解剖获取的E13.5 Fgfr2条件性敲除（Fgfr2cKO）小鼠与对照组小鼠的输尿管总RNA（total RNA）开展了检测。需注意，基因型标注中的“?”可代表“+”或“fl”，原因是Pax2cre/+;Fgfr1/+;Fgfr2fl/fl与Pax2cre/+;Fgfr1fl/fl;Fgfr2fl/fl两种基因型的输尿管均被收集至突变体混合样本中。