Typical western diet exacerbates dystrophic neurite pathology in APP/PS1 and APP/PS1/Tau mouse models by reducing the clustering of microglia around ß-amyloid plaques

Here, we studied the interaction between dietary (TWD) and genetic factors (APPswe/PS1dE9 and tau P301L mutations) and their effect on memory, brain pathology, global gene expression and on insulin-Akt-GSK3ß pathway in brain of mice with four different AD-linked genetic backgrounds: wild-type (AwTw), APPswe/PS1dE9 (A+Tw), P301Ltau (AwT+), and triple transgenic (A+T+). Overall design: The study comprised of 45 female mice, 12 wild-type (AwTw), 11 APP/PS1 transgenic (A+Tw), 12 tau P301L transgenic (AwT+) and 10 transgenic for both APP/PS1 and tau P301L (A+T+).