Spatial transcriptional changes induced by risperidone in a 3q29 schizophrenia-risk mouse model

This study investigated the effects of risperidone on gene expression in the coronal forebrain sections of adult male mice carrying the murine equivalent of the human 3q29 deletion - a rare copy number variant associated with a more than 40-fold increased risk of schizophrenia - bred at IF PAN. Sensorimotor gating was assessed twice using acoustic startle response and prepulse inhibition: first in drug-naive animals and again one week later following acute administration of risperidone (1 mg/kg) or saline. Brains were collected two hours post-treatment for spatial transcriptomic analysis. Coronal sections (1.54 to -1.18 mm from bregma) were mounted on Visium slides, stained, and processed to generate cDNA sequencing libraries.