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MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE130277
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In this study we report differences between MeCP2 isoforms (DNA binding ability, degradation rates and genomic binding) that reflect non-overlapping functions of the 2 proteins. ChIP seq of MeCP2 isoforms E1 and E2in mice frontal cortexes euthanized at 2 different times of the day (12 a.m. and 12 p.m.)
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2019-10-15
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