Atenolol: a Cardiovascular Safety Pharmacology Study Including Ventricular Contractility Using Radiotelemetry in Conscious Beagle Dogs Following Oral Administration

Radiotelemetry in n=4 male Conscious Beagle Dogs, dosed with atenolol at 10, 30 and 90 mg/kg po. No PK phase. Parameters measured: haemodynamic parameters (SAP, DAP, MAP, HR, LVEDP, TPR, CO, SV) and ECG parameters (RR, PR, QRS, QT, QTcF and QTcb intervals). Cardiovascular function (arterial blood pressure and electrocardiogram), body temperature and physical activity were recorded continuously for a period of at least 60 minutes before each dosing and for at least 24 hours following each dosing relative to dosing.