Expression data from RCC cell lines to study metastasis progression

This study investigates the molecular signatures that drive Renal Cell Carcinoma (RCC) metastatic conversion using the metastatic (LM2) and non-metastatic (SN12C) RCC cell lines. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. To identify differences in gene expression associated with increasing metastatic activity, we subjected the three RCC cell types, SN12C, LM1, LM2 to gene expression profiling.