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Integrative Genomic Analysis Reveals Widespread Enhancer Regulation by p53 in Response to DNA Damage

ChEBI2015-04-18 更新2026-07-21 收录

p53信号通路

增强子调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-55727 数据链接链接失效反馈

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Integrative Genomic Analysis Reveals Widespread Enhancer Regulation by p53 in Response to DNA Damage

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2015-04-18

小细胞肺癌表观遗传学

增强子调控

Additional file 6: Table S5. Super enhancers that are co-occupied by both ASXL3 and BRD4.

Figshare2020-07-16 更新90

PHF13 Activates Enhancers to Promote TGFβ-Induced Epithelial-to-Mesenchymal Transition [RNA-Seq]. PHF13 Activates Enhancers to Promote TGFβ-Induced Epithelial-to-Mesenchymal Transition [RNA-Seq]

上皮-间质转化机制

增强子调控

We investigated the role of PHF13 in TGFβ-induced Epithelial-to-Mesenchymal Transition and found PHF13 is essential for TGFβ-promoted broadest H3K4me3 domains and super-enhancers activation. Overall d

NIAID Data Ecosystem70

RNA sequencing analysis of NGFR ablation in both p53-positive and negative non-small-cell lung cancer cell lines. Homo sapiens

癌症基因表达

p53信号通路

We report the gene expression profiles by NGFR knockdown in H460 and H1299 cell lines and reveal that NGFR ablation activates p53 target gene expression. Overall design: We examined gene expression in

NIAID Data Ecosystem40

Identification of H3 Lysine 4 monomethylation Associated Proteins at Mammalian Enhancers

组蛋白修饰

增强子调控

Enhancers act to regulate cell type specific gene expression by facilitating the transcription of target genes. In mammalian cells active or primed enhancers are commonly marked by mono-methylation of

NIAID Data Ecosystem70

The small molecule compound P2 in HCT116p53-/- and HCT116p53+/+ cells

癌症基因表达分析

p53信号通路

Global gene expression in HCT116p53-/- and HCT116p53+/+ cells HCT116p53-/- and p53+/+ were untreated and treated with P2 small molecule compound at 25 microM, total RNA was isolated and gene expressio

NIAID Data Ecosystem50

Integrative Genomic Analysis Reveals Widespread Enhancer Regulation by p53 in Response to DNA Damage

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