Additional file 2 of Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes

Additional File 2: Tables S1-S9. Table S1: List of mature 150 miRNAs identified to be differnetially expressed in the diabetes-susceptible New Zealand Obese femlae mice. Table S2: Conservation of miRNA based on nucleotide sequence similarity in mouse and human. Table S3: miRNA-mRNA targets reported in 3 out of 5 databases and experimentally validated. Table S4: Putative protein targets for miRNAs. Both protein and miRNA are differentially expressed in the adipose tissue of the diabetes-susceptible mice. Table S5: Putative mRNA targets for miR-335-5p with fold changeand p value. Based on the known function of the gene, it was assigned to a particular categoryand CpGs annotated to miRNA genes that are also differnetially methylated. Table S6. 100 miRNAs in adipose tissue biopsies from 12 MZ twin pairs discordant for T2D matching with the differentially expressed miRNA in murine models. In bold P < 0.05, in red, the miRNA was newly identified, while the other have been presented in our previuos study. Table S7. Spearman statistics to assess correlation between the 100 miRNAs in adipose tissue biopsies from 12 MZ twin pairs discordant for T2D matching with the differentially expressed miRNA in murine models and blood glucose and HbA1c levels. Table S8. The 40 CpG sites in adipose tissue biopsies from 14 MZ twin pairs discordant for T2D corresponding to the 48 CpG sites from the mouse_MM285array annotated to the miRNA genes with differential expression in mouse models. In bold P < 0.05. The human data is based on our previous publication PMID: 24,812,430. Table S9. Spearman statistics to assess correlation between the 40 CpG sites in adipose tissue biopsies from 14 MZ twin pairs discordant for T2D corresponding to the 48 CpG sites from the mouse_MM285array and blood glucose and HbA1c levels. This analysis included both twins with and without T2D and is based on data from PMID: 24,812,430.