The Protein Digestion and Absorption Pathway in the Epidermis of Women Differed Across Different Age-Groups Proved by RNA-Seq

Skin plays a important role in protecting our physical body, what’s more, it also suffer from inner or outer threatens, which may cause the senescence of skin. Actually, various changes happened in the skin when it experience aging. Given that prominent macroscopic signs of senescence of skin include being drier, rougher, thinner, less glossy, and for microscopic views, reports proved that free radical, mitochondria, lysosome, telomere in cells have been changing with the process of aging, even some special genes which directly modulating cells’ fate also expressed differently between young and senior human’s skin. However, there are few articles for more detail and thorough cognition to transcriptome level differences across different age groups in epidermal cells so far. So we decided to detect and compare the overall mRNA levels in 7 cases of liquid nitrogen frozen woman’s epidermal sections which divided into young, middle-aged, senior groups by using RNA-Seq, for further investigation about what exact biological pathways may be affected by age change. Interestingly, we found that the protein digestion and absorption pathway associated genes expression were significantly disturbed by senescence in cells of epidermis. We hope our study can provide a more bright map for scientists to explore other relationship between senescence and genes.