A neuroprotective locus modulates ischemic stroke infarction independent of collateral vessel anatomy

The strains, C57BL6/J, C3H/HeJ, and WSB/EiJ, show a similar collateral vessel anatomy but differ infarct volume after ischemic stroke induction. To identify a gene(s) exhibiting differential gene expression, we performed RNA seq experiment within these mouse strains. Strain-specific differential expressed genes were examined from adult brain cortex of the strains ( 8-12 weeks old).C57BL6/J、C3H/HeJ与WSB/EiJ这三种小鼠品系的侧支血管解剖结构相似，但在缺血性脑卒中（ischemic stroke）造模后的脑梗死体积存在差异。为筛选出存在差异表达的基因，我们针对上述品系开展了RNA测序（RNA-seq）实验。我们采集8-12周龄成年小鼠的大脑皮层样本，对品系特异性差异表达基因进行了检测分析。