Additional file 2: of Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner

Associations of candidate gene expression in fetal placenta with maternal U-As. Multivariable linear regression analysis was performed to determine the association between log-transformed maternal U-As and log-transformed fetal placental expression of epigenetic candidate genes, in A) the unstratified cohort, B) males, and C) females. Analyses were adjusted for maternal age at enrollment. P values before and after FDR adjustment are shown (columns C-D). The effect of adjustment for urinary creatinine was also determined, by comparing the standardized beta values obtained from the subset of participants for which urinary creatinine data were available (â standardized_subset_betaâ , column P) with the equivalent values after adjustment for urinary creatinine (â standardized_subset_betaâ , column Q). Results of goodness-of-fit tests are also shown (columns S-T). (XLSX 124 kb)