SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant bound to inhibitor
收藏Protein Data Bank Japan2025-10-29 更新2026-04-11 收录
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SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant bound to inhibitor Descriptor: (1S,2S,4S)-2-{[3-cyclopropyl-N-(4-methoxy-1H-indole-2-carbonyl)-L-alanyl]amino}-1-hydroxy-4-methyl-5-(methylamino)-5-oxopentane-1-sulfonic acid, 3C-like proteinase Authors: Lu, J, Chen, P, Demmon, S, Fischer, C, Vederas, J.C, Lemieux, M.J. Deposit date: 2025-01-31 Release date: 2025-08-20 Last modified: 2025-10-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural insights into the nirmatrelvir-resistant SARS-CoV-2 M pro L50F/E166A/L167F triple mutant-inhibitor-complex reveal strategies for next generation coronaviral inhibitor design. Rsc Med Chem, 16, 2025
创建时间：
2025-01-31
