Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in Multiple Myeloma

We have strong evidence on the essential role of Che-1 protein in promoting the proliferation of MM cells by sustaining chromatin dynamics and cellular transcription on a global scale using numerous experimental approaches, including a generation of a specific transgenic mouse model. Overall design: Examination of RNA-seq, BRD4, H3K27ac, ATAC-seq, HDAC in KMS27 cell lines before and upon Che interference. ATAC-seq and RNA-seq data of wild and vk-Che mice (overexpression).