Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin

This is the public data repository for the the work presented in Croteau & Navarro et al. DOI: XXXX (TBC)

The repository contains 24 Spatial Transcriptomics (ST) datasets from tissue sections (hippocampus).

The sections were obtained from two Alzheimer´s disease mouse models:

- Tau22: over-expression of the Tau protein
- TauKO: knockout of the Tau protein

For each section, we have deposited the following:

- H&E file
- Matrix of counts (spots inside tissue)
- Raw matrix of counts with coordinates file
- Merged matrices of counts and meta files using in the downstream analyses.
- Results of the downstream analyses (DE analysis genes, pathways, etc...).

The scripts and notebooks used to analyse the data are available at https://github.com/jfnavarro/TAU22_KOTAU

The repository also contains all the Immunofluorescence (IF) images included in the manuscript.