M28 family peptidases from Peribacillus frigoritolerans initiates trained immunity to resist MRSA infections through activation of the Complosome-Phosphatidylcholine signaling axis

Methicillin-resistant Staphylococcus aureus (MRSA) represents a major global health threat due to its resistance to conventional antibiotics. The commensal microbiota maintains a symbiotic relationship with the host, playing essential roles in metabolism, energy regulation, immune modulation, and pathogen control. Mammals harbor a wide range of commensal bacteria capable of producing unique metabolites with potential therapeutic properties.