Metabolomics and microbiome revealed that C-phycocyanin alleviated the side effects of cisplatin chemotherapy in mice.

SPF six-week-old, male C57BL mice were purchased from Jinan Pengyue Experimental Animal Technology Co., Ltd. . Mice were fed under environmentally controlled conditions. Animal treatment was ratified by the Animal Protection Ethics Committee of Yantai University. Animal experiments were in live with Helsinki Declaration and international guidelines on animal experiment.The group named NC without radiotherapy with phycocyanin treatment, the group named CIS with phycocyanin intervention after chemotherapy treatment and the group named PC with phycocyanin intervention after chemotherapy treatment. phycocyanin PBS buffer solution was intragastrical administered to mice in PC group and NC group for three weeks.