Paired differential gene expression and splicing analyses results of 199 baseline vs. case comparisons across 100 datasets (Limma)

OBS! This is the limma results of the analysis. See https://doi.org/10.5281/zenodo.7032090 for the DESeq2/DEXSeq results.<br> <br> This dataset contains results from paired differential expression and differential splicing analyses as well as gene-set over-representation analysis results for 199 baseline vs. case comparisons across 100 randomly curated datasets with accompanying metadata (preprint).<br> All results were computed using the R package pairedGSEA, which utilized Limma (Ritchie et al., 2015) and fgsea (Korotkevich et al., 2019).<br> <br> Each .RDS file contains a list with four objects: A 'metadata' object with the metadata of the respective raw data, a 'genes' object with gene-level differential splicing and expression results, a 'gene_set' object with over-representation results, and 'experiment' with the experiment title.<br> <br> The filenames follow this pattern: "[dataset ID]_[GEO accession number]_[Manually assigned comparison title].RDS".<br> <br> All datasets were obtained from a local copy of the ARCHS4 v11 database of transcript counts (Lachmann et al., 2018).