Crude and multivariate-adjusted hazard ratios for the cardiovascular composite endpoint in patient subgroups stratified according to urinary albumin excretion rate and the CVD-AI.

Subjects were categorized as being above or below a UAER of 20 µg/min and above or below the CVD-AI cut-off value of −1.662. Crude (unadjusted) and adjusted hazard ratios were calculated using Cox proportional hazards regression models.aEstimates were adjusted for the conventional risk factors of cardiovascular disease, including age, sex, HbA1c, total cholesterol, triglyceride, high density lipoprotein cholesterol, estimated glomerular filtration rate, body mass index and hypertension.Abbreviations: CVD-AI, cardiovascular disease-amino acid based index; UAER, urinary albumin excretion rate.