Crystal structure of 11 beta-HSD1 in complex with SAR184841
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Crystal structure of 11 beta-HSD1 in complex with SAR184841 Descriptor: 4-[5-(4-tert-butylpiperazin-1-yl)pyridin-2-yl]-N-[(1R,2S,3S,5S,7s)-5-carbamoyltricyclo[3.3.1.1~3,7~]dec-2-yl]-3,4-dihydroquinoxaline-1(2H)-carboxamide, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Loenze, P, Schimanski-Breves, S, Engel, C.K. Deposit date: 2012-11-09 Release date: 2013-05-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Discovery of SAR184841, a potent and long-lasting inhibitor of 11beta-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D Bioorg.Med.Chem.Lett., 23, 2013
创建时间：
2012-11-09
