Effect and Mechanism of Chemically Modified CAMP mRNA Delivery to Oral Epithelial Cells in Mice with Periodontitis

Periodontitis is a chronic progressive inflammatory disease characterized by gum inflammation and alveolar bone destruction caused by bacterial infection. Porphyromonas odontidis in the oral cavity of periodontitis patients stimulated some defense cells of periodontal tissue to release excessive inflammatory mediators, causing inflammatory response, which led to the destruction of periodontal tissue. However, the existing more common physical mechanical therapy can not be effectively removed plaque accumulation, antibiotic treatment will bring resistance and patient allergies and other problems, so it is necessary to develop new treatment methods. LL-37 has inhibitory effects in fibroblast response complexes composed of porphyromonas gingivalis, stimulating toll-like receptors (TLRs) that initiate intracellular signaling cascades that trigger host inflammatory responses. In the inflammatory response caused by porphyromonas gingivalis, LL-37 exerts immunosuppressive effects in a paracrine manner. Therefore, this study will build a new model of delivery of chemically modified antibacterial peptide CAMP mRNA to oral epithelial cells of periodontitis mice, study the effect and mechanism of delivery of chemically modified antibacterial peptide CAMP mRNA to oral epithelial cells of periodontitis mice, and provide a new theoretical basis for the prevention and treatment of periodontal and oral mucosal infectious diseases such as periodontitis.