Crystal structure of an allosteric inhibitor bound to human RIPK1 kinase domain

Crystal structure of an allosteric inhibitor bound to human RIPK1 kinase domain Descriptor: DI(HYDROXYETHYL)ETHER, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1, ... Authors: Maskos, K, Johannsson, S, Kempf, G, Neumann, L, Cross, J.B. Deposit date: 2025-01-09 Release date: 2025-12-24 Last modified: 2026-01-28 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Allosteric targeting of RIPK1: discovery of novel inhibitors via parallel virtual screening and structure-guided optimization. Rsc Med Chem, 16, 2025