Cryo-EM structure of ATP8B1-CDC50A in E2P active conformation with bound PC

Cryo-EM structure of ATP8B1-CDC50A in E2P active conformation with bound PC Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Dieudonne, T, Kummerer, F, Juknaviciute Laursen, M, Stock, C, Kock Flygaard, R, Khalid, S, Lenoir, G, Lyons, J.A, Lindorff-Larsen, K, Nissen, P. Deposit date: 2023-05-01 Release date: 2023-11-29 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: Activation and substrate specificity of the human P4-ATPase ATP8B1. Nat Commun, 14, 2023