miR-19b microRNA binds PTEN mRNA

MicroRNA miR-19b, encoded by two genomic loci, MIR19B1 and MIR19B2, is homologous to miR-19a and also binds to the 3'UTR of PTEN mRNA (Polseno, Salmena, Zhang et al. 2010). miR-19b microRNA causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-19b microRNA also functions as a part of the nonendonucleolytic RISC.

MicroRNA miR-19b，由两个基因组位点MIR19B1和MIR19B2编码，与miR-19a同源，并可与PTEN mRNA的3'非翻译区（3'UTR）结合（Polseno, Salmena, Zhang 等人，2010年）。miR-19b微RNA导致PTEN mRNA及蛋白水平降低，因而表现出作为内切核酸酶RISC（RISC）组成部分的功能。可能miR-19b微RNA亦充当非内切核酸酶RISC的组成部分。