Memory like NK cells display stem cell like properties after Zika virus infection. Memory like NK cells display stem cell like properties after Zika virus infection

In this study, we show that CD27+ memory like NK cells generated following Zika virus infection exhibited stem-like features viz., self-renewal pathway, differentiation into effector cells and longer telomeres, and greater therapeutic potential than CD27- and naive CD27+ NK cells when adoptively transferred to Zika virus infected mice. In addition, epigenetic landscape of CD27+ memory like NK is markedly different compared to CD27- NK cells. Overall design: ATACseq of naive, CD27+ (stem cell like memory) and CD27- (nonmemory) NK cells in triplicates using Illumina HiseqX.