A very short and efficient synthesis of protected derivatives of APTO and AETD, the complex polyhydroxylated β-amino acid residues present in microsclerodermins C, D, and E, is described. The targets
Gaussian 16 AVX2 version and C01 revision single point energy refinement using the geometry optimised structure from the corresponding def2tzvpp calculation
Stereodefined monocyclic, spirobicyclic, and bis-spirotricyclic pyrazolidin-3-ones can be prepared efficiently by a three-component reaction involving a 1,3-dipolar cycloaddition of azomethine imines
