Dietary methionine restriction impairs anti-tumor immunity in part through gut microbiota

Dietary methionine restriction has been reported to repress cancer growth and improve therapeutic responses in several pre-clinical settings. We show that the impact of dietary methionine restriction on tumor growth and anti-tumor immunity is partially dependent on gut microbiota-mediated non-cell autonomous activation of immune cells. Methionine restriction alters composition of gut microbiota and reduces microbial production of hydrogen sulfide. There is a vital role of gut microbiota in mediating methionine restriction-induced suppression of anti-tumor immunity.