Direct, Catalytic Enantioselective Nitroaldol (Henry) Reaction of Trifluoromethyl Ketones: An Asymmetric Entry to α-Trifluoromethyl-Substituted Quaternary Carbons
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https://figshare.com/articles/dataset/Direct_Catalytic_Enantioselective_Nitroaldol_Henry_Reaction_of_Trifluoromethyl_Ketones_An_Asymmetric_Entry_to_Trifluoromethyl_Substituted_Quaternary_Carbons/2973400
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资源简介：
Herein we describe the first direct, catalytic enantioselective nitroaldol (Henry) reaction of simple α-trifluoromethyl ketones with nitromethane
using a chiral monometallic lanthanum(III) triflate salt complex, namely [(Δ,S,S,S)-Binolam]3·La(OTf)3, as enantioselective catalyst. The resulting
α-trifluoromethyl tertiary nitroaldols were obtained in moderate to high yields (up to 93%) and enantioselectivities (up to 98% ee). These
adducts are versatile chiral building blocks and may be reduced (NiCl2/NaBH4) to their β-amino-α-trifluoromethyl tertiary alcohols without loss
of enantiomeric purity.
创建时间：
2016-06-03
