Bacillus coagulans BC99 mitigates ionizing radiation-induced intestinal injury in mice by modulating microbes and metabolites

This study aimed to evaluate the radioprotective effects of B.co BC99 on the intestinal tract and related mechanisms. The results showed that B.co treatment can mitigate RIII by maintaining the integrity of intestinal structure and barrier, improving inflammatory symptoms, modulating oxidative stress, and regulating the composition of intestinal microbiota, thereby reestablishing intestinal homeostasis. In addition, we found that the potential radioprotective mechanism of B.co BC99 is closely related to the Gut microbiota-derived metabolics.