Altered Duodenal Mucosa-Associated Microbiota and Immune Profiles in Functional Dyspepsia: A Study of Host-Microbiome Homeostasis

Recent work suggests an altered duodenal mucosa-associated microbiota (MAM) for patients with functional dyspepsia (FD), when compared to healthy individuals. These differences may reflect alterations in host-microbiome homeostasis, although study numbers are low and consensus on specific biomarker signatures within the microbiome have not been reached. Given that specific mucosal immune signatures have been identified in FD, we hypothesised that these changes would be associated with specific microbial changes. We aimed to profile the duodenal MAM to identify microbes associated with known changes in FD mucosal and peripheral immune homeostasis.