Expression data of tumor and non-tumor liver tissues from Peruvian patients with hepatocellular carcinoma (HCC)

A large fraction of HCC in Peru arises in younger, non-cirrhotic patients. Transcriptomic analysis of the HCC and non-tumor liver (NTL) tissues highlights a divergent gene expression profile that coincides with Amerind haplogrouping. This metagene is also associated with a peculiar molecular signature that does not conform with the current molecular classifications of HCCs. We used microarrays to compare gene expression between tumors and non-tumor counter parts in order to identify genes and ontologies that are differentially expressed. HCC patients were treated by anatomic liver resection. Non-tumor liver tissues were obtained from tumor-free margins of resected surgical pieces. Total RNA was extracted from flash-frozen samples for hybridization on Affymetrix microarrays.