RNA and ATAC sequencing of BMDCs after stimulation via FcRgamma
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https://www.ncbi.nlm.nih.gov/sra/DRP010587
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资源简介：
To understand the effects of Fc receptor gamma chain (FcRgamma) signaling on gene transcription, we examined chronological chromatin accessibility and gene expression using five conditions of bone marrow-derived dendritic cells (BMDCs): M. bovis Bacille de Calmette et Guerin (BCG) stimulation in signal molecule- or receptor-deficient cells; mannose-capped lipoarabinomannnan (LAM) or trehalose-6,6-dimycolate (TDM) stimulation; TDM stimulation via constitutively expressing Mincle; spleen tyrosine kinase (Syk) inhibitor-treated LAM stimulation; anti-CD8 antibody stimulation via CD8/FcRr-chimeric receptor. From all RNA and ATAC-seq data, we found that the kinetics of FcRgamma signaling is converted into distinct chromatin status and generates different gene expression profiles in dendritic cells.
创建时间：
2023-09-30
