LIN28B promotes differentiation of fully transformed AML cells but is LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression. LIN28B promotes differentiation of fully transformed AML cells but is LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression

MLL-AF9 driven AML cells regress when LIN28B is ectopically expressed.RNA-seq was performed to measure LIN28B expression and associated changes in gene expression Overall design: MLL-AF9 virus was used to induce AML from widtype or tet-on LIN28B rogenitors. After leukemia engraftment, LIN28B expression was induced in experimental mice by feeding Doxycycline chow. AML were harvested 6 days later to assess gene expression.