Bulk mRNA-seq of blood samples of visceral leishmaniasis patients during active disease and after treatment (cured), asymptomatic individuals and healthy uninfected control volunteers.

To ascertain which genes are involved in the outcome of Leishmania infantum infections and immunopathology of human visceral leishmaniasis (VL), we investigated the transcriptional profile of whole blood samples from patients during active VL compared to the same patients 180 days after being treated, when they were considered clinically cured. Also, we compared VL transcriptional profile to asymptomatic individuals (positive serology for Leishmania, but without clinical signs of disease) and healthy uninfected control samples.