Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis [RNA-seq]

To determine which signaling pathway may have been affected by HDAC8, we designed NEC mice model with PCI34051 supplementation. We then performed gene expression profiling analysis using data obtained from RNA-seq of intestinal tissues (control group, NEC group, PCI34051+NEC group) treated with PCI34051 (10 mg/kg/d). Comparative gene expression profiling analysis of RNA-seq data for intestinal tissues from control or NEC mice under the condition of PCI34051 (10 mg/kg/d,once a day for 5 days) treatment.