MSC-NK co-culture, D14, MSC5 (phenotype)

To assess MSC modulation of NK receptor expression,we co-cultured NK from healthy donors with MSCs from patients with lung cancer and with non-tumor-associated MSCs isolated from the same patients. We tested inhibitors of MSC secretion or the neutralization of MSC secreted factors to assess whether or not we could affect MSC downregulation of NK receptors.