Crystal structure of GDC-0927 bound to estrogen receptor alpha
收藏Protein Data Bank Japan2024-03-13 更新2026-03-21 收录
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Crystal structure of GDC-0927 bound to estrogen receptor alpha Descriptor: (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-6-ol, Estrogen receptor Authors: Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Wang, X, Zbieg, J.R, Labadie, S.S, Li, J, Ray, N.C, Ortwine, D. Deposit date: 2019-06-21 Release date: 2019-07-17 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Bioorg.Med.Chem.Lett., 29, 2019
创建时间：
2019-06-21
