Characterization of human aging and Parkinson’s disease pre-frontal cortex by multi-omics: a glycomics, proteomics study.

This study identifies the age and PD related changes in glycans (HS and CS disaccharides) and proteomics in human aging and Parkinson’s disease. We analyzed the prefrontal cortex for changes in HS, CS and proteomic signatures in young versus aged as well as aged and PD in two cohorts. These studies provide insight into age- and PD changes in glycans and proteomics. We assess changes with PD and observe for pathways that may correlate with transcriptomics. We also observe in aging related proteomic changes and transcriptomics for changes in common with PD that may describe risk of disease.