piRNA production requires heterochromatin formation in Drosophila
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
Here, we analyzed H3K9me3 derived from wild type ovarian tissue. Here we show that deposition of histone 3 lysine 9 by the methyltransferase dSETDB1 (egg) is required for piRNA cluster transcription. In the absence of dSETDB1, cluster precursor transcription collapses in germline and somatic gonadal cells and TEs are activated, resulting in germline loss and a block in germline stem cell differentiation. We propose that heterochromatin protects the germline by activating the piRNA pathway.
提供机构：
NYU/HHMI
创建时间：
2022-02-20
