Practical Asymmetric Synthesis of Amathaspiramides B, D, and F
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https://figshare.com/articles/dataset/Practical_Asymmetric_Synthesis_of_Amathaspiramides_B_D_and_F/3168742
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资源简介:
The practical asymmetric synthesis
of amathaspiramides B, D, and
F has been accomplished by utilizing an aza-Barbier allylation as
the key step to construct the common intermediate with two adjacent
stereocenters. A kinetically controlled cyclization to build the challenging
thermodynamically less stable 8R-hemiaminal moiety
is also important in the synthesis of amathaspiramide D. The route
is readily scalable, and gram quantity of the final product D has
been prepared.
创建时间:
2016-05-02



