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Practical Asymmetric Synthesis of Amathaspiramides B, D, and F

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NIAID Data Ecosystem2026-03-09 收录
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https://figshare.com/articles/dataset/Practical_Asymmetric_Synthesis_of_Amathaspiramides_B_D_and_F/3168742
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The practical asymmetric synthesis of amathaspiramides B, D, and F has been accomplished by utilizing an aza-Barbier allylation as the key step to construct the common intermediate with two adjacent stereocenters. A kinetically controlled cyclization to build the challenging thermodynamically less stable 8R-hemiaminal moiety is also important in the synthesis of amathaspiramide D. The route is readily scalable, and gram quantity of the final product D has been prepared.
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2016-05-02
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