Photoredox-Catalyzed Intermolecular Hydroalkylative Dearomatization of Electron-Deficient Indole Derivatives

Dearomatization of indole derivatives
offers a straightforward
approach to access diverse indolines. To date, the corresponding dearomative
transformations involving electron-deficient indoles are limited.
Herein, we report a one-electron strategy for dearomatization of electron-deficient
indoles via a photoredox-catalyzed hydroalkylation employing commercially
available glycine derivatives as the hydrofunctionalization reagents.
Followed by DBU-mediated lactamization, structurally appealing lactam-fused
indolines are obtained in good to excellent yields with exclusive
selectivity.