Additional file 6 of Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7

Additional file 6. Ingenuity Pathways Analysis (IPA) of DEGs specific to the AP by comparison with the UM. (.xlsx). Significantly enriched: (A) Pathway and (B) Disease-related GO terms are shown, with the p-value and the DEGs from which each term was derived. (C) The top 1500 DEGs from the AP vs. UM comparison (based upon fdr/adj p-value) were input into the Percayai suite's CompBio pathway analysis tool to obtain networks associated with these DEGs. These networks were filtered with a concept filter utilizing the search terms "Wnt AND neuronal migration" to identify a network of interconnected themes (shown); concepts and underlying genes (entities) within each theme in the network above are shown. (D) Genes (entities) present in the Wnt AND Neuron Migration/Cadherin AND neural/interneuron themes are shown. These include two genes (GJA1/TGFBR2) that overlapped between Wnt-related and neuronal migration-related DEGs also called by Ingenuity Pathway Analysis. n = 4; data values are in Additional file 5.