Chromosome gene,Hsl7 gene in vitro studies

The submission literature is talking a important gene Hsl7,recently report it might related with disease and it control cell translation process, Protein methylation is a type of post-translational modification that involves the addition of methyl groups to proteins. It can occur on the nitrogen-containing side-chains of arginine and lysine, but also at the amino- and carboxy-termini of a number of different proteins.Methylation can occur on multiple sites of proteins. For instance, arginine can be methylated once (monomethylated arginine) or twice (dimethylated arginine). Methylation of arginine residues is catalyzed by three different classes of protein arginine methyltransferases (PRMTs). Type I and II PRMTs both generate N G-monomethylarginine intermediates; PRMT7, the only known type III PRMT, produces only monomethylated arginine.Protein methylation, including histone methylation and non-histone protein methylation, is one of the most important forms of posttranscriptional and epigenetic modifications. It has effects on autophagosome formation, autophagy-related protein expression, and signaling pathway activation.