An oligonucleotide was circularized around double-stranded DNA thanks to triple helix formation. Short oligonucleotides are known to be able to form DNA triple helices by binding into the DNA major gr
It is estimated that ~2 billion people worldwide cannot afford even basic medicines. Bioreactor-produced recombinant protein therapies (BRPTs), among the world’s most-expensive medicines, have revolut
BACKGROUND: Attempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer and expression in the airway epi
