VRprofile

The antibiotic resistance genes (ARGs) often gain mobility through associating with a set of mobile genetic elements (mobilome). Their concerted activities significantly contribute to the promiscuous spread of ARGs throughout the microbial community. Here, we report the release of VRprofile version 2.0, which offers three major enhancements: (i) graphical representation of the multiple resistance regions with mosaic structures and comparison to the known MGEs with similar architecture; (ii) aid to explore the relationships of antibiotic resistance genes, mobile elements, and host strains; (iii) pre-computed mobilome of more than 5500 ESKAPEE bacterial genomes.抗生素抗性基因（Antibiotic Resistance Genes, ARGs）通常通过与一组移动遗传元件（mobile genetic elements, MGEs，又称移动组，mobilome）结合而获得移动性，二者的协同作用显著推动了ARGs在整个微生物群落中的无差别扩散。本研究报道了VRprofile 2.0版本的发布，该工具具备三项核心改进：(i) 可视化展示具有镶嵌结构的多重抗性区域，并与具有相似结构的已知移动遗传元件进行比对；(ii) 辅助探究抗生素抗性基因、移动元件与宿主菌株之间的关联；(iii) 提供了覆盖超过5500株ESKAPEE细菌基因组的预计算移动组数据集。

搜集汇总

背景与挑战

背景概述

VRprofile 2.0是一个用于检测细菌病原体中抗生素耐药性相关移动基因组的数据集。它通过图形化表示耐药区域、分析耐药基因与移动元件及宿主菌株的关系，以及预计算超过5500个ESKAPEE细菌基因组的移动基因组，帮助研究耐药性传播机制。