Calcium time series of cortex in a rat model of cortical dysplasia

In vitro Calcium time series of rat (P30) primary motor cortex, were recorder by a CCD camera coupled to stereo-fluoerscence<br> microscope, with a fs = 300ms, following the next sequence: <strong>Basal, <em>Stimulus</em>, Rest.</strong> All data is included in a compressed file named <strong>calcium_timeseries.tar.gz.</strong> There are two groups of rats: <strong>Control</strong> (control animals), and <strong>BCNU</strong> (experimental animals using the BCNU/carmustine model of cortical dysplasia [1]). Time series are stored in .<strong>csv</strong> files with file names as <strong>R?Pilo-KCl.csv</strong> (where <strong>?</strong> indicates the rat ID). Each of these files holds the two recordings, one for each <em>Stimulus</em>, the first being <em>pilocarpine</em>, followd by <em>KCl</em> used as a control of cellular activity. (pilocarpine, KCl). recording session: The first 150 seconds of these time series correspond to basal activity, followed by 30 s of pilocarpine stimulus, and the rest of spontaneous activity after stimulation, for a total of 15 minutes for each <em>Stimulus</em>. The number of cells recorded varied between animals, as indicated by the number of columns in these .csv files. All of these files have the same number of rows (6000), with each row indicating a frame in the time series. The file <strong>dataEx.png</strong> illustrates this organization. Files named <strong>R?-Coor.csv</strong> (<strong>?</strong> indicates rat ID) show the <em>x</em> and <em>y</em> coordinates of every recorded cell, one for each row, ordered as<br> they appear in the calcium activity recordings. <br> Authors: Ana Aquiles [e-mail] Tatiana Fiordelisio [e-mail] Hiram Luna-Munguía [e-mail] Luis Concha [e-mail] 1. Benardete, E. A., &amp; Kriegstein, A. R. (2002). Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex. <em>Epilepsia</em>, <em>43</em>(9), 970-982.