Regional transcriptomics and mechanical properties of rat Achilles tendons

The transcriptome of different tendons varies based on anatomical location and is likely influenced by the biomechanical loading environment. While differences in biologic and mechanical properties of whole tendons have been assessed, less is understood about differences within a tendon along its proximal-distal axis. Therefore, our objective was to determine the characteristics of and relationship between the transcriptomes and mechanical properties of a single tendon.不同肌腱的转录组（transcriptome）会随解剖位置的不同而发生变化，且很可能受到生物力学加载环境的影响。尽管学界已针对完整肌腱的生物学与力学特性差异开展了相关评估，但对于单条肌腱沿近-远轴的内部差异仍知之甚少。因此，本研究旨在明确单条肌腱的转录组与力学特性的特征及其相互关联。