Effect of cardiomyocyte-specific deletion of Gch1 on gene expression

To investigate the physiological role of BH4 in cardiac function, we developed mice with cardiomyocyte-specific deletion of (cm)Gch1, the gene that encodes for GTPCH, which responsible for de novo synthesis of BH4. We performed RNA sequencing in heart tissues from cmGch1 KO and WT mice. Comparative gene expression profiling analysis of RNA-seq data for cmGch1 KO and WT mice