Impact of Chronic Olanzapine Administration on Gene Expression in the Mouse Lateral Septum

To explore the effects of long-term olanzapine treatment on gene expression in the lateral septum of female mice, we conducted a study using female C57BL/6 mice fed with olanzapine-supplemented chow for 12 weeks. The treated mice exhibited significant weight gain and lipid alterations compared to the control group. Subsequently, RNA-seq was performed on the lateral septum brain regions of both the treated and control mice, followed by gene expression profiling to analyze the data. Overall design: In this study, we investigated the impact of prolonged olanzapine administration on the lateral septum of female C57BL/6 mice. The mice were divided into two groups: the experimental group received chow supplemented with olanzapine for 12 weeks, while the control group was fed standard chow. After the treatment period, we observed significant differences in weight and lipid profiles between the two groups. RNA sequencing was then performed on the lateral septum brain regions of both groups to identify changes in gene expression profiles, providing insights into the molecular effects of long-term olanzapine exposure in female mice.