Dynamic lipid mediator changes support infiltrating macrophage subtype transitions during skeletal muscle injury and regeneration
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Time-dependent profiles were recapitulated in sorted neutrophils and Ly6Chigh and Ly6Clow muscle macrophages, with a distinct pro-resolving signature observed in Ly6Clow reparative macrophages. RNA-seq analysis of macrophages stimulated with resolvin D2 (RvD2) showed similarities to transcriptional changes found during the temporal Ly6Chigh to Ly6Clow phenotypic transition. Importantly, RvD2 promoted the temporal progression from Ly6Chigh to Ly6Clow macrophages in vivo.
提供机构：
University of Debrecen
创建时间：
2022-02-20
